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Xiaoming Yuan,Jiahui Chen,Ning Zhang,Qiang Ye,Changle Li,Chunsheng Zhu,Xuemin Sherman Shen,
《工程(英文)》 doi: 10.1016/j.eng.2023.04.015
关键词: Knowledge sharing Internet of Vehicles Federated learning Broad learning Reconfigurable intelligent surfaces Resource allocation
Rapid and long-effective removal of broad-spectrum pollutants from aqueous system by ZVI/oxidants
Sana Ullah, Xuejun Guo, Xiaoyan Luo, Xiangyuan Zhang, Siwen Leng, Na Ma, Palwasha Faiz
《环境科学与工程前沿(英文)》 2020年 第14卷 第5期 doi: 10.1007/s11783-020-1268-3
关键词: Zero-Valent Iron (ZVI) Oxidants Heavy Metals (HMs) Metalloids Nitrate Phosphate
从H1N1血凝素序列提取的沙门氏菌传递的COBRA-HA1抗原对甲型流感亚型产生广谱保护作用 Article
Ram Prasad Aganja, Amal Senevirathne, Chandran Sivasankar, John Hwa Lee
《工程(英文)》 2024年 第32卷 第1期 页码 42-57 doi: 10.1016/j.eng.2023.08.001
A universal vaccine is in high demand to address the uncertainties of antigenic drift and the reduced effectiveness of current influenza vaccines. In this study, a strategy called computationally optimized broadly reactive antigen (COBRA) was used to generate a consensus sequence of the hemagglutinin globular head portion (HA1) of influenza virus samples collected from 1918 to 2021 to trace evolutionary changes and incorporate them into the designed constructs. Constructs carrying different HA1 regions were delivered into eukaryotic cells by Salmonella-mediated bactofection using a Semliki Forest virus RdRp-dependent eukaryotic expression system, pJHL204. Recombinant protein expression was confirmed by Western blot and immunofluorescence assays. Mice immunized with the designed constructs produced a humoral response, with a significant increase in immunoglobulin G (IgG) levels, and a cell-mediated immune response, including a 1.5-fold increase in CD4+ and CD8+ T cells. Specifically, constructs #1 and #5 increased the production of interferon-γ (IFN-γ) producing CD4+ and CD8+ T cells, skewing the response toward the T helper type 1 cell (Th1) pathway. Additionally, interleukin-4 (IL-4)-producing T cells were upregulated 4-fold. Protective efficacy was demonstrated, with up to 4-fold higher production of neutralizing antibodies and a hemagglutination inhibition titer > 40 against the selected viral strains. The designed constructs conferred a broadly protective immune response, resulting in a notable reduction in viral titer and minimal inflammation in the lungs of mice challenged with the influenza A/PR8/34, A/Brisbane/59/2007, A/California/07/2009, KBPV VR-92, and NCCP 43021 strains. This discovery revolutionizes influenza vaccine design and delivery; Salmonella-mediated COBRA-HA1 is a highly effective in vivo antigen presentation strategy. This approach can effectively combat seasonal H1N1 influenza strains and potential pandemic outbreaks.
关键词: COBRA Influenza A Salmonella Vaccine Broad spectral protection
High risk factors for pulmonary fungous infection in intensive care units of neurosurgery
ZHU Wenyu, TAN Liping, CHEN Xiangfeng, HUANG Qiang, LAN Qing
《医学前沿(英文)》 2007年 第1卷 第3期 页码 299-303 doi: 10.1007/s11684-007-0057-8
关键词: seventeen incidence glucocorticoid broad-spectrum antibiotic Candidiasis
《环境科学与工程前沿(英文)》 2023年 第17卷 第6期 doi: 10.1007/s11783-023-1677-1
● MSWNet was proposed to classify municipal solid waste.
关键词: Municipal solid waste sorting Deep residual network Transfer learning Cyclic learning rate Visualization
Spatial prediction of soil contamination based on machine learning: a review
《环境科学与工程前沿(英文)》 2023年 第17卷 第8期 doi: 10.1007/s11783-023-1693-1
● A review of machine learning (ML) for spatial prediction of soil contamination.
关键词: Soil contamination Machine learning Prediction Spatial distribution
Elucidate long-term changes of ozone in Shanghai based on an integrated machine learning method
《环境科学与工程前沿(英文)》 2023年 第17卷 第11期 doi: 10.1007/s11783-023-1738-5
● A novel integrated machine learning method to analyze O3 changes is proposed.
Machine learning in building energy management: A critical review and future directions
《工程管理前沿(英文)》 2022年 第9卷 第2期 页码 239-256 doi: 10.1007/s42524-021-0181-1
关键词: building energy management machine learning integrated framework knowledge evolution
《化学科学与工程前沿(英文)》 2022年 第16卷 第2期 页码 183-197 doi: 10.1007/s11705-021-2073-7
关键词: machine learning flowsheet simulations constraints exploration
Machine learning for fault diagnosis of high-speed train traction systems: A review
《工程管理前沿(英文)》 doi: 10.1007/s42524-023-0256-2
关键词: high-speed train traction systems machine learning fault diagnosis
张乃通,张中兆,初海彬,刘会杰
《中国工程科学》 2002年 第4卷 第10期 页码 11-16
介绍了国际上出现的三种星座通信系统,重点分析了几个具有代表性系统的组成、结构、功能及其存在的问题。探讨了卫星移动通信系统的发展趋势,并对发展卫星移动通信做了几点思考。
Dynamic prediction of moving trajectory in pipe jacking: GRU-based deep learning framework
《结构与土木工程前沿(英文)》 页码 994-1010 doi: 10.1007/s11709-023-0942-5
关键词: dynamic prediction moving trajectory pipe jacking GRU deep learning
Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature
《医学前沿(英文)》 2023年 第17卷 第4期 页码 768-780 doi: 10.1007/s11684-023-0982-1
关键词: machine learning methods hypertrophic cardiomyopathy genetic risk
《机械工程前沿(英文)》 2022年 第17卷 第2期 doi: 10.1007/s11465-022-0673-7
关键词: deep reinforcement learning hyper parameter optimization convolutional neural network fault diagnosis
Automated synthesis of steady-state continuous processes using reinforcement learning
《化学科学与工程前沿(英文)》 2022年 第16卷 第2期 页码 288-302 doi: 10.1007/s11705-021-2055-9
关键词: automated process synthesis flowsheet synthesis artificial intelligence machine learning reinforcement learning
标题 作者 时间 类型 操作
Low-Cost Federated Broad Learning for Privacy-Preserved Knowledge Sharing in the RIS-Aided Internet of
Xiaoming Yuan,Jiahui Chen,Ning Zhang,Qiang Ye,Changle Li,Chunsheng Zhu,Xuemin Sherman Shen,
期刊论文
Rapid and long-effective removal of broad-spectrum pollutants from aqueous system by ZVI/oxidants
Sana Ullah, Xuejun Guo, Xiaoyan Luo, Xiangyuan Zhang, Siwen Leng, Na Ma, Palwasha Faiz
期刊论文
从H1N1血凝素序列提取的沙门氏菌传递的COBRA-HA1抗原对甲型流感亚型产生广谱保护作用
Ram Prasad Aganja, Amal Senevirathne, Chandran Sivasankar, John Hwa Lee
期刊论文
High risk factors for pulmonary fungous infection in intensive care units of neurosurgery
ZHU Wenyu, TAN Liping, CHEN Xiangfeng, HUANG Qiang, LAN Qing
期刊论文
MSWNet: A visual deep machine learning method adopting transfer learning based upon ResNet 50 for municipal
期刊论文
Elucidate long-term changes of ozone in Shanghai based on an integrated machine learning method
期刊论文
Using machine learning models to explore the solution space of large nonlinear systems underlying flowsheet
期刊论文
Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature
期刊论文
A new automatic convolutional neural network based on deep reinforcement learning for fault diagnosis
期刊论文